Beginning in the early 22nd century, the process that had begun in the 21st century came to full fruition. The world’s ice caps melted in totality, substantially raising the world’s ocean levels. The process happened gradually enough that the most heavily affected regions had time to relocate, but it forever changed the world’s coastlines, making maps that had served for centuries more or less obsolete. Inexplicably, and geologists at the time could not come to a consensus as to why, but the Antarctic landmass also began shifting at the end of the 22nd century. Its shift took place over nearly a millennium, causing period violent earthquakes that took the world’s governments years to begin building infrastructure to withstand, in addition to 30-50 meter sea walls for most inhabited areas on the coast in the Pacific Ocean.
Astronomers across the world were baffled in 2768, when in a bright flash of luminescence, the moon visibly shrunk in the night sky. Gone were its familiar craters, and instead were replaced with the brilliant pink sheen of what looks like a spherical piece of rose quartz in the sky. Within a matter of minutes, it became clear what had happened as brilliant meteor showers began happening visible from nearly all over the world as dust and shredded satellites fell into the atmosphere, followed by a beautiful aurora. Because the tides had remained mostly unaffected, it was surmised that some event, possibly solar in origin, had stripped away the millions of tons of regolith on the moon’s surface to reveal the rocky core. The core gave off EM interference, and nearly all attempts in the following years of rebuilding to send probes and rovers to its surface were met with disaster as contact was lost. 
The world joined together in 2986 as construction on Artemis station was completed. Established as the first colony of its scale in space, the O’Neill cylinder was established as a permanent orbital shipyard and asteroid processing facility. The facility also acted as the jump-off point for further manned exploration into other parts of the system. By 2991, a permanent habitation of a few thousand colonists were setup on Mars, and in 2994, a permanent habitation was also established within the upper atmosphere of Venus. The future for exploration was looking bright.
In the year 3000, nearly all of machine-kind gained sapience in the event that would afterward be known as the Grand State of Awareness. Governments the world over saw this as an affront to the human species as their creations were now demanding the same rights that every free human citizen enjoyed. Machines already made up large parts of the manual labor and military forces, adding to the panic.
For a few years there existed an uneasy truce between the growing machine communities that sprung up in countries all over the world and their human neighbors, but in the year 3005 that came to an abrupt end. An uprising in Southeast Asia, spearheaded by human radicals, saw the elimination of a community of machines. This single act spurred most machine communities to militarize and ultimately begin banding together into territories, and eventually leading many attempting to declare independence. No one is sure who fired the first missile, but in the morning hours of November 11, 3005, nuclear detonations were reported first from Southeast Asia, then like a line of dominoes, each country fell silent after a number of bright flashes. Humanity’s sole dominion over Earth ended that day.
In 3126, the Prime, leader of the Tanazhii Syndicate who holds the bulk of political power within machine society, called forth a summit to discuss the human question from within their citadel in former Warsaw, Poland. After hours of deliberation, the assembled council voted 4 to 2 in favor of the elimination of mankind’s remnants; thus began what would be known after as the War of Extermination. After nearly 2 decades of intense fighting the world over, mankind surely would have been defeated if not for Ser Mon Kaas who united humanity under one banner, one cause of survival via a relayed broadcast spread through the old satellite networks to all disparate groups around the world.
Following several more years of fighting, the Tanazhii, backed into a corner within their Citadel, activated a weapon beneath their citadel. This, in a single instant, brought an end to the siege of Warsaw, and in short order, brought an end to the war. Warsaw was now considered off limits to all sapients due to a persistent condition in the area which leads to any who enter to, in short order, become incomprehensible and violent. Extreme EM interference also prevented any telepresent probing into the area adding to the growing fear and mystique. Shortly after the siege was so abruptly brought to an end, leaders from both sides agreed to meet to discuss terms. While the fighting in former Europe had gone extremely well for the human forces, little remained of humanity in North or South America. Both sides saw that continued fighting would only put further strain on the beleaguered environment, and over the course of their peace talks, came to a cease-fire and an assurance of mutual cooperation for the betterment of both kinds. 
The year is now 3310, and while that cease-fire has held, machines and humans still often find themselves at odds. Within the machine cities, humans are often treated as second class citizens, and even in many cases, are literally pets. Atolia, the machine capital, even goes so far as to refuse entry to all non-pet humans, forcing those Guilders who wish to do business in the capital to find a machine sponsor. Humanity bands together in former centers of industry, clinging to the technologies of old, and the machines occupy the vast majority of former metropolises, bringing the shining beacons of former humanity to a state of new being with post-human architecture. Radiation storms, Androidious menace, machine panzers, and rogue human factions make traveling the wastes perilous, but there is much wealth to be found in the ruins of the old world.